Identifying and diagnosing patients with metal hypersensitivity MELISA® TESTING IN ORTHOPAEDICS
نویسنده
چکیده
Patients suffering from metal hypersensitivity may have local symptoms associated with an overactive immune response such as localised pain, swelling, cutaneous allergic reactions, joint and muscle pain, implant failure or recurrent suspected infections around the operation site. Also, systemic reactions such as fibromyalgia and chronic fatigue can be exacerbated or triggered by metal hypersensitivity.
منابع مشابه
LTT-MELISA is clinically relevant for detecting and monitoring metal sensitivity.
OBJECTIVES Chronic low-level metal exposure may result in metal sensitization and undesirable side-effects. The main sources of metal exposure are from the environment or from corrosion of dental metal alloys. Affected patients are routinely diagnosed with the epicutaneous (patch) test. However, such testing may induce false-positive (irritative) reactions and may in itself sensitize or exacerb...
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OBJECTIVE This study was carried out to evaluate the reproducibility, sensitivity, specificity, and reliability of the MELISA Test for detecting metal sensitivity in patients with clinical symptoms of a type IV hypersensitivity to metal. DESIGN Blood from 250 patients was tested in MELISA against up to 20 different metals in 2 to 3 concentrations. The frequency and distribution of metal react...
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تاریخ انتشار 2014